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Inhibition by Theophylline of Phagocytosis in Acanthamoeba castellanii (1976)

LEWIS, M. B. ; WEISMAN, R. A.

Oxford, UK : Blackwell Publishing Ltd

The @journal of eukaryotic microbiology 23 (1976), S. 0

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ISSN: 1550-7408

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: SYNOPSIS. Theophylline inhibited the phagocytosis of latex beads by Acanthamoeba castellanii (Neff). The cells recovered the ability to engulf beads after 1–2 hr of exposure to theophylline. Cells which have been exposed to 25 mM theophylline for a period of inhibition and recovery were not inhibited further by incubation with a fresh medium containing the same concentration of theophylline. However, the medium in which the cells recovered was as effective as a fresh medium in inhibiting phagocytosis in a fresh batch of cells, suggesting that the development of insensitivity to theophylline inhibition resides with the cells themselves. Dibutyryl cyclic AMP also inhibited bead uptake.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1550-7408.1976.tb03784.x

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