Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
The @journal of eukaryotic microbiology
8 (1961), S. 0
ISSN:
1550-7408
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
Notes:
Resistance to sulfanilamide has persisted in a strain of Chilomonas Paramecium for 255 transfers (63 months) in a drug-free medium. In attempts to modify resistance, stocks derived from sulfonamide-resistant and normal strains have been acclimatized to and then maintained in media containing p-aminobenzoic acid at 5.0, 10.0, 15.0 and 20.0 mgJ100 ml. Each PABA-acclimatized strain was more susceptible to sulfanilamide than its parent stock. In other words, sulfanil-amide-resistant strains lost their resistance and normal strains became hypersensitive. One strain, adapted first to sulfanilamide, subsequently to PABA (15 mgJ100 ml) and again to sulfanilamide, showed a loss of and finally a restoration of sui-fonamide-resistance (but to a degree somewhat lower than the original level).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1550-7408.1961.tb01215.x
|
Location |
Call Number |
Expected |
Availability |
