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REPORT OF STUDIES ON MONOCLONAL ANTI-IgG ANTIBODIES (1990)

Voak, D. ; Nilsson, U.

Oxford, UK : Blackwell Publishing Ltd

International journal of immunogenetics 17 (1990), S. 0

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ISSN: 1744-313X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology , Medicine

Notes: Eleven monoclonal anti-IgG antibodies were evaluated by ten laboratories for possible AHG reagent use by the ISBT/ICSH protocol. Three of the anti-IgGs were selected by tests with weak Fya sensitized cells as this represents the best screening test. One of the IgM class anti-IgGs (205) equalled ISBT/ICSH reference reagents (R3P and RIIIM) against weak anti-D, -K and Fya sensitized cells and it reacted with all four subclasses of IgG. Thus, subject to satisfactory stability and extended trials with a wide range of weak antibodies, monoclonal anti-IgGs for AHG reagent use are now a possible alternative to conventional rabbit anti-IgG.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1744-313X.1990.tb00884.x

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