ISSN:
1662-0356
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Natural Sciences in General
,
Technology
Notes:
Three-dimensional biodegradable porous scaffolds play an important role in tissueengineering as temporary templates for transplanted cells to guide the formation of the new organs.Two kinds of novel biodegradable porous scaffolds for tissue engineering have been developed byour group by hybridizing synthetic poly(α-hydroxy acids) with naturally derived collagen. One istheir hybrid sponge prepared by introducing collagen microsponges in the pores of poly(α-hydroxyacids) sponge. The other one is their hybrid mesh prepared by forming collagen microsponges in theinterstices of poly(α-hydroxy acids) mesh. The hybrid scaffolds were used for three-dimensionalculture of fibroblast, tenocytes, chondrocytes and mesenchymal stem cells for tissue engineering ofskin, ligament, cartilage and osteochondral tissue. These cells adhered and spread well in the hybridscaffolds, proliferated, secreted extracellular matrices and formed the respective tissues. Thesynthetic polymer sponge, or mesh serving as a skeleton, reinforced the hybrid scaffolds andresulted in easy handling, while the collagen microsponges provided the hybrid sacffolds with amicroporous structure and hydrophilicity, and therefore, easy cell seeding. The hybrid scaffolds willbe useful for tissue engineering
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.49.136.pdf
