ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Our previous studies showed that synthetic octacalcium phosphate (OCP) enhances boneregeneration more than hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). Also, a syntheticbone substitute constructed of synthetic octacalcium phosphate (OCP) and porcine atelocollagensponge (OCP/Col) showed stable bone regeneration. The present study was designed to investigatethe difference of bone regeneration by OCP/Col and other calcium phosphate-collagen composites.OCP/Col, β-TCP$-collagen% composite (β-TCP/Col), or HA$-collagen% composite (HA/Col) spongewas prepared from pepsin-digested atelocollagen isolated from the porcine dermis and OCP, β-TCP,or HA granules, respectively. A standardized critical-sized defect was made in the rat calvarium, andvarious calcium phosphate-collagen composites were implanted into the defect. The rats were fixedat four weeks after implantation and radiographic and histological examinations were performed byundecalcified cross sections of implants. Radiographic examination showed that uniform radiopaquemasses were observed in the created defects treated with OCP/Col, whereas granulous and foggyradiopacity was observed in β-TCP/Col and HA/Col. Histological examination showed that newlyformed bone was observed in the reticulum of OCP/Col and around the implanted OCP. Theregenerated bone by β-TCP/Col or HA/Col seemed to be less than that by OCP/Col and would not tobe nucleated by the granules of β-TCP or HA. The present study indicated that bone regeneration byOCP/Col was different from those of β-TCP/Col and HA/Col. Application of OCP/Col would beexpected for clinical use in the future
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1229.pdf
