ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
To develop a suitable scaffold for tissue-engineered bone regeneration, we compared theefficiency of tissue-engineered bone regeneration according to the porous structure of calciummetaphosphate (CMP) ceramic scaffolds. Each scaffold was prepared with a sponge method and afoam-gel method, respectively. Both scaffolds, having either interconnected trabecular pores formedby the sponge method or fully interconnected globular pores formed by the foam-based technology,were not cytotoxic and elicited neither an immune nor an inflammatory response regardless ofgeometry and fabrication method. The fully interconnected globular porous scaffold showed morefavorable compression strength and facilitated osteogenic repair by favoring cellular attachment andosteogenic differentiation with good osteoconductivity compared to the interconnected trabecularpore structured scaffold. These results suggest that the fully interconnected globular porous structurewould be more suitable for both a bone substitute and scaffold for bioactive material-based orcell-based tissue bone regeneration
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.935.pdf
