ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The present work describes the development of biomimetic materials for osteochondraltissue substitution and repair, which can be the start for a revolution in the classical procedures oforthopedic surgery. Performing biomineralization process, we succeeded to prove that biologicalsystem store and process information at the molecular level. The substitute consist in three layers:the lower layer, mimicking bone tissue, is formed by HA/Collagen (70/30)wt; the intermediatelayer, mimicking the tade-mark, is formed by HA/Collagen (40/60)wt; and the upper layer,mimicking the cartilagineous layer, is formed by Collagen containing Hyaluronic Acid. In vivo testsperformed on small and large size animals should that: the bony portion well integrate andgradually are reabsorbed in contact with femoral bone in rabbit. The osteochondral substituteshowed the ability to repair defect in osteochondral lesion opened in horses knee and differentlystimulate cells thanks to the different chemico-morphological-microstructural features of thescaffold layer
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.927.pdf
