ISSN:
1013-9826
Quelle:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Thema:
Maschinenbau
Notizen:
Hydrophobically modified derivative of a γ-cyclodextrin, functionalized withperfluoro alkyl ester group, was prepared and investigated for its potential use as asustained release carrier for water-soluble drug molsidomine, a peripheral nitrovasodilatorused in the treatment of angina pectoris. The molecular encapsulation of molsidomine bythe amphiphilic cyclodextrin, octakis(6-O-perfluorobutanoyl)-γ-cyclodextrin (γ-CyD-F),was confirmed by DSC and XRD studies. The in-vitro release of molsidomine frompeanut oil suspensions into aqueous phase was found to be significantly retarded by thecomplexation with γ-CyD-F, mainly due to the hydrophobic properties of the γ-CyD-F
Materialart:
Digitale Medien
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.493.pdf