ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Hydrotropic block copolymers, consisting of a hydrophilic poly(ethylene glycol) (PEG)block and a hydrotropic polymer, poly(2-(4-(vinyl benzyloxy)-N,N-diethylnicotinamide))[P(VBODENA)], block, were synthesized by atom transfer radical polymerization (ATRP) foraqueous solubilization of paclitaxel, a representative poorly water-soluble drug. These polymersshowed an excellent solubilizing effect for paclitaxel in aqueous media in comparison with thecorresponding hydrotropic agent and a control micelle (PEG-PLA) and such effect was significantlydependent on the polymer concentration and composition. Paclitaxel could be solubilized intopolymer micelles in aqueous media without use of an organic solvent. Due to their promisingproperties such as micellar characteristics and hydrotropic solubilization, the hydrotropic polymermicelle system can be useful for formulation of paclitaxel and other poorly soluble drugs
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.421.pdf
