ISSN:
1399-0047
Source:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Topics:
Chemistry and Pharmacology
,
Geosciences
,
Physics
Notes:
The X-ray structure of the inhibitor complex of bovine ribonuclease A with cytidylic acid (2′-CMP) has been determined at 1.6 Å resolution and refined by restrained least squares to R = 0.17 for 11 945 reflections. Binding of the inhibitor molecule to the protein is confirmed to be in the productive mode associated with enzyme activity. A study of conserved solvent sites amongst high-resolution structures in the same crystal form reveals a stabilizing water cluster between the N and C termini.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1107/S090744499300719X