ISSN:
1612-1112
Keywords:
Gas chromatography
;
Headspace analysis
;
Gonadotrophins
;
Residual solvents
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A headspace, gas chromatographic method for determining residual solvents in pharmaceutical products such as the gonadotrophin powders, has been developed. The method allows the determination of residual solvents by transferring the samples directly into a vial contianing 10 mL 2M sodium chloride; the analysis is carried out by sampling the headspace and separating by capillary gas chromatography using a programmedtemperature vaporizer (PTV) injector. The procedure described is simple, sensitive and reproducible. The lower limit of detection is 20 ppb for ethyl alcohol, 8 ppb for acetone and 0.5 ppb for diethyl ether.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02274577
