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PCR detection of structurally abnormal Y chromosomes (1992)

Nagafuchi, Shigeo ; Seki, Satoko ; Nakahori, Yutaka ; [et al.]

Springer

Journal of human genetics 37 (1992), S. 187-193

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ISSN: 1435-232X

Keywords: PCR ; STS ; Y chromosome ; deletion mapping

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Three probes each detecting a locus on the proximal long arm of the Y chromosome were partially sequenced. Thus, 3 sets of novel primers were developed which enable PCR detection of these 3 loci. Five previously reported primer sets, 3 on the short arm and each one on the centromere and the distal long arm, were mapped along with the novel three using a mapping panel consisted of 8 patients each with different structural abnormality of the Y chromosome. Now, PCR detection of these 8 loci covering an entire length of the Y chromosome has become possible enabling rapid screening of patients with Y chromosome aberrations.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01900712

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