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  • 1
    Electronic Resource
    Electronic Resource
    Finding the lowest free energy conformation of a protein is an NP-hard problem: Proof and implications (1993)
    Springer
    Bulletin of mathematical biology 55 (1993), S. 1183-1198 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The protein folding problem and the notion of NP-completeness and NP-hardness are discussed. A lattice model is suggested to capture the essece of protein folding. For this model we present a proof that finding the lowest free energy conformation belongs to the class of NP-hard problems. The implications of the proof are discussed and we suggest that the natural folding process cannot be considered as a search for the global free energy minimum. However, we suggest an explanation as to why, for many proteins, the native functional conformation maycoincide with the lowest free energy conformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02460703
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