Electronic Resource
Springer
Bulletin of mathematical biology
34 (1972), S. 483-502
ISSN:
1522-9602
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Mathematics
Notes:
Abstract In vivo control of calcium is analysed under the assumption that hormonal influences via plasma levels of parathormone and calcitonin are of prime (but not absolutely dominating) importance. A brief review concerning the physiological significance of body calcium and the mode of action of these two hormones is presented as an introduction to the basic philosophy of the study. A theoretical quasi-linear lumped-parameter model is developed to describe variations in ionic calcium, parathormone and calcitonin plasma concentrations to specific input stimuli. Formal evaluation of the system response requires the determination of ten constants, together with quantitation of ingested calcium entry into the plasma compartment which isindependent of hormonal influences. Values for various parameters are deduced from published data and experimental procedures are outlined to facilitate determination of the remaining unknowns. It is suggested that the proposed model should prove useful for investigations concerning general hormonal actions on calcium homeostatic mechanisms in both normal and diseased states, with particular reference to calcitonin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02476710
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