ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract Adult rhesus monkeys were given a single dose of 1.5 or 3.0 g of a polychlorinated biphenyl (PCB) (Arochlor 1248) per kg body weight and sacrificed four days later. In addition, one monkey from each group was placed in a metabolism cage and the excreta collected during a two-week period and analyzed for PCB content. Over 90 percent of the single PCB dosage was absorbed from the gastrointestinal tract and deposited in various tissues of the body. Elimination of the PCBs, primarily through the biliary system, occurred at a slow rate. The monkeys did not become obviously ill following ingestion of the PCBs, but developed moderate hepatic enlargement due primarily to an increase in lipid droplets and proliferation of the endoplasmic reticulum of the hepatic cells. Gastric hypertrophy and hyperplasia and focal ulceration of the stomach lining were prominent lesions in these animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01985803
