ISSN:
1432-0878
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary An electron microscope study of the reactive process taking place in the proximal segment of sectioned dorso-spinal nerves of white mice was carried out in about 50 animals. Attention was mainly directed to the study of the earliest changes (30′) observable in the neuroplasm but the series of experiments included the study of nerves fixed up to 20 days after section. Most of the facts found (existence of microvesicles, multiplication of mitochondria, and presence of multivesicular bodies) confirmed the observation done in a preceding investigation, plus some non-described new findings. Early after section (30′) the nerve membrane is seen, in some cases, masked by the presence of microvesicles which seem to take origine from the membrane which also shows deep infoldings. These coalesce in many places taking thus the appearance of rows of vesicles. At later stages (60′, 80′) this reactive process is more general in the nerve stumps and vast areas of microvesicles are seen in the fiber neuroplasm. This kind of reaction (membrane infolding and coalescence) decrease later on and is rarely observable at 100′. Microvesicles are nevertheless increasing in number and many of them change their round profile for an elongated shape. Elongation leads to the formation of tubuli of progressively thinner diameter. This process is described as a possible way of neurofilament formation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00319067
