ISSN:
1432-0878
Keywords:
Kidney
;
Triturus cristatus carnifex
;
Erythropoiesis
;
Electron microscopy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Specimens of Triturus cristatus carnifex (Laurenti), raised in 3.2 g/l solution of sodium lactate, presented hypertrophy of “lactate sensitive cells” (LSC) clustered at the vascular pole of each renal corpuscle. As seen under both the light and electron microscopes, these are specialized cells of the Bowman's capsule located at the junction between its visceral and parietal layers. The structure formed by the cells, heretofore unknown, is topographically associated with the juxtaglomerular apparatus. As lactate stimulates erythropoiesis even in normal oxygenated specimens and hypoxia induces hypertrophy of LSC in newts, it is hypothesized that the LSC are the site of erythropoietin (ESF) synthesis. A scheme of ESF biogenesis in newts, integrating the above principles, concludes the paper.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00237808
