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Effects of halothane on microtubules in the sciatic nerve of the rat (1979)

Livingston, A. ; Vergara, G. A.

Springer

Cell & tissue research 198 (1979), S. 137-144

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ISSN: 1432-0878

Keywords: Microtubules ; Halothane ; Sciatic nerve (Rat) ; Repolymerisation

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The effect of halothane and colchicine on microtubule repolymerisation after exposure to cold has been examined in the sciatic nerve of the rat. Myelinated axons showed a significant decrease in microtubule numbers and density after exposure to both 20 mM halothane and 10−5 M colchicine; exposure to both agents simultaneously produced a further significant reduction when compared to halothane alone. It is suggested that halothane can interfere with microtubule repolymerisation in mammalian axons possibly in a similar way to that described in invertebrates.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00234841

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