ISSN:
1432-1203
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Acute and chronic treatment of Chinese hamsters and mice with 5, 25 and 125 mg/kg isoniazid (INH) given by oral intubation did not enhance the chromosomal aberration frequencies in spermatogonia. The structural and numerical aberration rates remained in the range of spontaneous events even after the chronic treatment over 12 weeks with 3×125 mg/kg INH per week. This dose is much higher than normally used for prevention and therapy in man (3–16 mg/kg).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00291622