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  • 1
    Electronic Resource
    Electronic Resource
    Induction of cytoplasmic respiratory deficient mutants in yeast by the folic acid analogue, methotrexate (1973)
    Springer
    Molecular genetics and genomics 126 (1973), S. 61-70 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The folic acid analogue, methotrexate, was found to be an effective inducer of the cytoplasmic petite mutation in different strains of S. carlsbergensis and S. cerevisiae. The induction varies considerably from strain to strain and also with growth conditions under which the experiments are carried out. Determination of mitochondrial protein synthesis in the presence of methotrexate shows a considerable decrease in incorporation of radioactive leucine before any significant induction of petites has taken place. These results and a comparison with results from other laboratories obtained with different drugs provide the basis for a proposed mechanism of petite induction by methotrexate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333482
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