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Fission yeast tmsl protein abrogates normal development in Xenopus laevis embryos (1995)

Wagner, Peter ; Hoever, Michael ; Appel, Katrin ; [et al.]

Springer

Development genes and evolution 204 (1995), S. 198-202

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ISSN: 1432-041X

Keywords: tms1 ; fission yeast ; Xenopus laevis development

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Recently we cloned tms1 (a putative dehydrogenase) by complementation of a human tumour-derived mutant p53 induced growth arrest in fission yeast. Microinjection of purified tmsl protein into Xenopus laevis embryos abrogated normal embryo development by causing cleavage retardation or cleavage arrest of injected blastomeres in a concentration dependant manner, whereas injection of specific affinity purified tms1 antiserum showed no significant morphological defects. Microinjection of tms1 protein together with affinity purified tms1 antibody resulted in a significantly reduced number of cleavage arrested embryos.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00241273

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