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Repair of cellular radiation damage in space under microgravity conditions (1999)

Pross, H. D. ; Kiefer, J.

Springer

Radiation and environmental biophysics 38 (1999), S. 133-138

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ISSN: 1432-2099

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Physics

Notes: Abstract The influence of microgravity on the repair of x-ray-induced DNA double-strand breaks was studied in the temperature-conditional repair mutant rad54–3 of diploid yeast Saccharomyces cerevisiae. Cells were exposed on the ground and kept at a low temperature until microgravity conditions were achieved. In orbit, they were incubated at the permissive temperature to allow repair. Before re-entry they were again cooled down and kept at a low temperature until final analysis. The experiment, which was flown on the shuttle Atlantis on flight STS-76 (SMM-03), showed that repair of pre-formed DNA double-strand breaks in yeast is not impaired by microgravity.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004110050149

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