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  • 1
    Electronic Resource
    Electronic Resource
    The mechanism for the methionine mediated reduction of anthramycin yields inStreptomyces refuineus fermentations (1976)
    Springer
    Applied microbiology and biotechnology 2 (1976), S. 95-101 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The addition of L-methionine to cultures ofStreptomyces refuineus producing anthramycin, results in an apparent decrease in the antibiotic titer. It has been shown that this effect is not due to the inhibition of tyrosinase, an enzyme implicated in anthramycin biosynthesis. The inhibitory effect also appears unlikely to be due to a regulatory role played by methionine in a non-precursor fashion. Experiments with radiolabeled anthramycin have revealed that the reduced yields of the antibiotic are due to the interaction of anthramycin with generated reactive metabolites produced in the methionine-supplemented cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00942352
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