ISSN:
1432-0614
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary The metabolism of Alcaligenes eutrophus is both qualitatively and quantitatively affected by the availability of oxygen as is documented by the in vivo excretion of several distinct metabolites. Intermediates of the tricarboxylic acid cycle are produced because the dehydrogenases catalyzing the subsequent steps of metabolism become inhibited in a sequential order by increasing NADH levels which are caused by lack of oxygen. Simultaneously, other enzymes which cannot be detected when the cell's oxygen demand is satisfied, i.e., formate dehydrogenase, fumarate reductase, butanediol, lactate, and ethanol dehydrogenases are induced in a sequential order enabling the cells to produce the corresponding metabolites. The molecular mechanism by which dehydrogenases involved in the fermentative metabolism are derepressed under lack of oxygen is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00499517
