ISSN:
1432-1041
Keywords:
Tetracycline absorption
;
iron salts
;
drug absorption
;
man
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The inhibitory effect of various iron salts, all containing 40 mg elemental iron, on the absorption of tetracycline (500 mg) administered simultaneously has been compared in a double-blind cross-over study in 6 healthy human volunteers. On the basis of changes in peak serum tetracycline concentration, area under individual serum tetracycline concentration-time curves and urinary excretion of tetracycline, the following order of inhibition of tetracycline absorption was found: ferrous sulphate 〉 ferrous fumarate, ferrous succinate, ferrous gluconate 〉 ferrous tartrate 〉 ferric sodium edetate. Thus, in addition to different pharmaceutical properties of iron tablets or capsules, the type of iron salt used may significantly influence the absorption of simultaneously ingested tetracycline.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558206
