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Pharmacokinetics of practolol in renal failure (1974)

Bodem, G. ; Grieser, H. ; Eichelbaum, M. ; [et al.]

Springer

European journal of clinical pharmacology 7 (1974), S. 249-252

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ISSN: 1432-1041

Keywords: Practolol ; renal failure ; uraemia ; beta-blockade ; pharmacokinetics ; man

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The effect of renal failure on the excretion of oral doses of practolol has been studied. The plasma half-life increased up to 6.6 times normal and the cumulative urinary excretion of the drug was reduced. There was a linear correlation between the overall elimination rate constant of practolol and inulin and creatinine clearances. A linear correlation was also found between the renal clearances of practolol and inulin. The dose of practolol required for maintenance therapy should be reduced in patients with impaired renal function.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00560339

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