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Protein binding of digoxin in human serum (1972)

Ohnhaus, E. E. ; Spring, P. ; Dettli, L.

Springer

European journal of clinical pharmacology 5 (1972), S. 34-36

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ISSN: 1432-1041

Keywords: Digoxin ; protein binding

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The protein binding of digoxin in human serum was investigated using equilibrium dialysis and tritium-labelled digoxin. A constant protein bound fraction of about 30% was found over a wide range of concentrations of digoxin including therapeutic levels. Interpretation of the findings according to the law of mass-action showed an association constantK = 0.68·10−5l/mol; and, the number of binding sites,n → ∞, indicating an almost infinite apparent maximum binding capacity and a very small affinity of human serum proteins for digoxin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00560893

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