ISSN:
1432-1041
Keywords:
Baclofen
;
severe spasticity
;
pharmacokinetics
;
CSF
;
intrathecal injection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l·h−1. In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00265844