ISSN:
1432-1041
Keywords:
flecainide acetate
;
Wolff-Parkinson-White syndrome
;
rectal absorption
;
suppository
;
micro enema
;
bioavailability
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The rectal absorption of flecainide from an aqueous solution, a fatty suppository and a polyethyleneglycol suppository was studied in one patient with supraventricular tachycardia (Wolff-Parkinson-White syndrome) refractory for oral anti-arrhythmic treatment. Rectal absorption was found to be fast (t1/2abs=1 h) and complete when flecainide was administered as a solution (relative bioavailability 100%). Flecainide was poorly absorbed from a fatty suppository. The polyethyleneglycol suppository gave absorption with a relative bioavailability of 80% and t1/2 abs=1.2 h.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00555514
