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Rapid gas chromatographic determination of phenobarbital in small plasma samples (1971)

Kållberg, N. ; Agurell, S. ; Jalling, B. ; [et al.]

Springer

European journal of clinical pharmacology 3 (1971), S. 185-188

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ISSN: 1432-1041

Keywords: Pharmacokinetics ; repeated plasma determinations

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary A gas chromatographic method is described for the determination of phenobarbital in 50–100 µl plasma samples. After ether extraction at slightly acid pH, phenobarbital is reextracted with a small volume of aqueous trimethylanilinium hydroxide which also serves as an “on column” methylating agent. The method is suitable for pharmacokinetic analysis in man and laboratory animals using repeated capillary blood sampling, and for control of plasma levels in patients on phenobarbital treatment.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00572462

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