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Pinacidil, a new vasodilator, in the treatment of patients with moderate to severe hypertension (1984)

Koliopoulos, K. ; Papadoyannis, D. E. ; Karatzas, N. B.

Springer

European journal of clinical pharmacology 27 (1984), S. 287-289

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ISSN: 1432-1041

Keywords: pinacidil ; hypertension ; vasodilator ; patients ; side-effects

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary A new vasodilator drug, pinacidil, N″-cyano-N-4-pyridyl-N′-1, 2,2-trimethylpropylguanidine, was studied in an open trial in 15 patients with moderate to severe hypertension. Four patients received pinacidil monotherapy, and in 11 patients it was used with a diuretic or a beta-blocker. In all but one patient normotension was achieved with a mean daily pinacidil dose of 46.7 mg b.i.d. (range 20–100 mg). Side effects were few and were action-related. There was no evidence of early toxicity. Pinacidil is a promising new antihypertensive vasodilator, which deserves further clinical evaluation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00542161

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