ISSN:
1432-1041
Keywords:
theophylline
;
asthma
;
slow release theophylline
;
reversible obstructive airways disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Theophylline concentrations were measured in a clinical setting in 15 patients given a slow release theophylline preparation (Theo-Dur) every 12 h for reversible obstructive airways disease. Doses of 300–600 mg (464±134), 12 hourly, resulted in mean serum concentrations which increased from 11.2±2.9 µg/ml at 0 h to a peak of 15.5±4.6 µg/ml at 6 h and decreased again to 10.4±2.9 µg/ml at 12 h. The mean percentage fluctuation of serum concentrations (maximum minus minimum expressed as a % of the maximum) was 38.6±10.1%, range 20.3% to 54.9%. There was a significant positive correlation between % fluctuation and theophylline steady-state clearance determinations. Excluding a single heavy smoker, theophylline clearance also showed a significant inverse relationship with age. These data suggest that when this slow release preparation is given 12 hourly, satisfactorily sustained serum theophylline concentrations will be achieved in most adults.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00613818
