ISSN:
1432-1041
Schlagwort(e):
disopyramide
;
protein binding
;
vacutainer®
;
alpha-1-acid-glycoprotein
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary Serum and plasma disopyramide (D) protein binding was compared after blood was collected from four normal subjects in various Vacutainer® tubes. The fraction of disopyramide bound to proteins in control serum and plasma was drug concentration dependent and correlated well with the capacity factor (N) associated with a high affinity protein binding site. D free fraction increased 60% at a post-equilibrium concentration of 2 µg/ml in plasma following exposure of blood to green-top Vacutainer® stoppers due to a 60% reduction in the affinity constant associated with the high affinity protein binding site. Heparin and EDTA had no effect on the plasma protein binding of D. These results suggest a competitive inhibition of disopyramide binding to α1-acid-glycoprotein following contact of blood with rubber Vacutainer® stoppers.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00542466
