ISSN:
1432-072X
Keywords:
Malate dehydrogenase
;
Inactivation
;
Glucose metabolism
;
Glyceraldehyde-3-phosphate
;
Saccharomyces cerevisiae
;
Glyoxylate cycle
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The cytoplasmic malate dehydrogenase in the yeast Saccharomyces cerevisiae is known to be inactivated by a glucose dependent process. In this paper it is shown that in vivo effectors of the glucose metabolism (arsenate, iodoacetate, acetaldehyde) inhibit the inactivation or change the inactivation kinetics. In vitro it was possible to inactivate the malate dehydrogenase by addition of the glucose metabolite glyceraldehyde 3-phosphate. The physiological relevance of this modification and the effect of malate dehydrogenase inactivation on the glyoxylate cycle in yeast is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00427845
