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Transfer-RNA, an early gene? (1981)

Eigen, Manfred ; Winkler-Oswatitsch, Ruthild

Springer

Naturwissenschaften 68 (1981), S. 282-292

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ISSN: 1432-1904

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General

Notes: Abstract The theory of self-reproductive molecular systems involves the consequence that translation must have started from a selected distribution of RNA molecules, that comprised GC-rich sequences of a length 〈 100 nucleotides. This implies a joint function of messenger and adaptor, which both had to be recruited from the same mutant distribution. The reconstruction of tRNA precursors yields such a molecule showing some reverberation of a codon pattern GNC. These findings suggest that tRNA has been the earliest component of the translation machinery.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01047470

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