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Germ-line chromosomal localization of humanc-erb-A oncogene (1985)

Jhanwar, Suresh C. ; Chaganti, R. S. K. ; Croce, Carlo M.

Springer

Somatic cell and molecular genetics 11 (1985), S. 99-102

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ISSN: 1572-9931

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The human germ-line position of c-erb-A,the cellular counterpart of v-erb-A,has been determined by in situ molecular hybridization of a 3H-labeled c-oncgene probe to meiotic pachytene chromosomes. Both v-erb-Aand v-erb-Bare the v-oncgenes that are associated with induction of sarcoma and erythroblastosis in chicken by the avian erythroblastosis virus, a rapidly transforming RNA tumor virus. The position of c-erb-A, determined here to be at 17q21.33–q22, is in the same region of chromosome 17 in which a nonrandom break occurs in the generation of t(15;17), a translocation commonly seen in acute promyelocytic leukemia.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01534740

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