ISSN:
1573-904X
Keywords:
furosemide
;
diuresis
;
sodium excretion
;
potassium excretion
;
chloride excretion
;
urinary excretion rate
;
urinary electrolytes in rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Furosemide effects are usually evaluated by measuring the urinary excretion rate of Na+ (UVNa) in humans. In the present study, however, UVNa showed a nonlinear relationship with urine flow rate after intravenous injection of furosemide in rats. In contrast, when the urinary excretion rate of (Na+ + K+) (UVNa+K) was plotted against the urine flow rate, a linear regression line was observed, with small interindividual variations in normal rats and in rats with uranyl nitrate-induced acute renal failure (ARF). Piretanide, a loop diuretic, also showed a similar relationship, while other types of diuretics revealed different slope values for the relationship. Although the urinary excretion rate of Cl− (UVC1) vs UVNa+K is expected to show a linear relationship in normal rats, the correlation coefficient of the linear regression line was smaller than that of the urine flow rate vs UVNa+K. Further, the slope of UVC1 vs UVNa+K was slightly different in ARF rats. Therefore, UVNa+K provides a better quantitative measure of diuretic response to loop diuretics than UVNa or UVC1.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015999626133
