ISSN:
1573-904X
Keywords:
ATR-FTIR
;
deuteration
;
diffusion coefficient
;
ethanol
;
glycerogelatin films
;
soft gelatin capsules
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The use of ATR-FTIR spectroscopy to study the permeability of a glycerogelatin film is described. Measurement of the diffusion coefficient of ethyl alcohol-d in the film showed excellent reproducibility. Comparison of results from this technique with those previously obtained using an air-flow receptor phase diffusion cell show good agreement in terms of lag time assessed diffusion coefficients. ATR-FTIR spectroscopy revealed time-dependent changes in the composition of the glycerogelatin film during the diffusional process. It was also demonstrated that the concurrent assessment of both diffusant penetration and film composition is feasible.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1016262215192