ISSN:
1573-9686
Keywords:
Reentry
;
Arrhythmias
;
Restitution
;
Stability
;
Electrophysiology
;
Simulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Technology
Notes:
Abstract We studied the stability of spiral waves in homogeneous two-dimensional cardiac tissue using phase I of the Luo–Rudy ventricular action potential model. By changing the conductance and the relaxation time constants of the ion channels, various spiral wave phenotypes, including stable, quasiperiodically meandering, chaotically meandering, and breakup were observed. Stable and quasiperiodically meandering spiral waves occurred when the slope of action potential duration (APD) restitution was 〈1 over all diastolic intervals visited during reentry; chaotic meander and spiral wave breakup occurred when the slope of APD restitution exceeded 1. Curvature of the wave changes both conduction velocity and APD, and their restitution properties, thereby modulating local stability in a spiral wave, resulting in distinct spiral wave phenotypes. In the LR1 model, quasiperiodic meander is most sensitive to the Na+ current, whereas chaotic meander and breakup are more dependent on the Ca2+ and K+ currents. © 2000 Biomedical Engineering Society. PAC00: 8719Hh, 8717Nn, 8717Aa, 8716Uv
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1114/1.1289474
