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Long-term potentiation and 4-aminopyridine (1985)

Haas, H. L. ; Greene, R. W.

Springer

Cellular and molecular neurobiology 5 (1985), S. 297-301

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ISSN: 1573-6830

Keywords: long-term potentiation ; 4-aminopyridine ; hippocampal slice

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary 1. Long-term potentiation (LTP) of excitatory postsynaptic potentials (epsp's) was investigated with extracellular field potential recording in hippocampal slices from rats. 2. In the presence of 100µM 4-aminopyridine (4-AP) the probability of eliciting LTP was unchanged or increased; the extent of potentiation was not significantly different from normal. 3. During LTP saturation, 4-AP further enhanced the epsp. 4. These data are inconsistent with an involvement of A-current reduction in LTP.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00711014

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