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Glycogenolytic effect of pancreastatin in the rat (1990)

Sanchez, Victor ; Calvo, Juan R. ; Goberna, Raimundo

Springer

Bioscience reports 10 (1990), S. 87-91

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ISSN: 1573-4935

Keywords: glycogen ; pancreastatin

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract Pancreastatin is a novel 49-amino acid peptide with a C-terminal glycine amide. The peptide was isolated from porcine pancreatic extracts and shows a structural similarity to chromogranin A. The effect of synthetic porcine pancreastatin on blood glucose levels and hepatic glycogen content was investigated in ratsin vivo. Pancreastatin (300 pmol/kg) produced a time-dependent decrease in glycogen content of liver and a slight hyperglycemia. Basal plasma insulin and glucagon levels were not modified by pancreastatin. We suggest that pancreastatin could play a biological role in the glucose metabolism through a glycogenolytic effect.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01116856

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