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Interaction between bradykinin, morphine, and naloxone at the sensomotor cortical unit level (1979)

Anisimov, Yu. Z. ; Bulaev, V. M. ; Sherstnev, V. V.

Springer

Bulletin of experimental biology and medicine 88 (1979), S. 1431-1433

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ISSN: 1573-8221

Keywords: opiate receptors ; neurons ; sensomotor cortex ; bradykinin ; morphine ; naloxone

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The effects of bradykinin, morphine, and naloxone applied by microiontophoresis on sensomotor cortical neurons were studied in waking rabbits. Bradykinin increased the discharge frequency of most neurons. Morphine inhibited unit activity. Against the background of morphine, bradykinin had no activating action. Naloxone abolished the depriming effect of morphine and restored the response of the neurons to bradykinin. It is concluded that bradykinin interacts with opiate receptors in the brain.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00830353

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