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  • 1
    Electronic Resource
    Electronic Resource
    Importance of the degree of aeration of the medium for the antibacterial action of drugs used in tuberculosis (1965)
    Springer
    Bulletin of experimental biology and medicine 59 (1965), S. 285-287 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The degree of the inhibiting concentration of isoniazid, kanamycin ethionamide, ethambutol and D,L-cycloserine with regard toM. tuberculosis var. avium increases with a decrease in the oxygen content of the medium. The inhibiting concentration of D-cycloserine does not depend on the oxygen content of the medium. The bactericidal effect of isoniazid on tuberculosis mycobacteria grows with an increase in the aeration of the medium and slows down with its decline. An analogous relationship in a somewhat lesser degree was revealed in experiments with D,L- and D-cycloserine and was manifest slightly, if at all, in experiments with ethionamide, ethambutol and kanamycin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00783191
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