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Search for catalytic properties of simple polypeptides (1987)

Barbier, B. ; Brack, A.

Springer

Origins of life and evolution of the biospheres 17 (1987), S. 381-390

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ISSN: 1573-0875

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Geosciences

Notes: Abstract Simple polypeptides were used as possible supports for nucleotide polymerization, in the absence of any preformed polynucleotide template. Sequential copolymers of alanine and glycine, water soluble polypeptides based on arginine and poly(Glu-SerGlu) have been tested. No catalytic effect has been found although poly(Glu-Ser-Glu) favors the 2′–5′ internucleotide linkage. More interestingly, polypeptides containing arginine residues strongly accelerate the hydrolysis of oligoadenylic acids. The influence of pH, temperature, nature of the buffer and polypeptide sequence was investigated.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02386476

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