ISSN:
1573-899X
Keywords:
End-plate miniature currents
;
acetylcholine
;
post-synaptic membrane
;
desensitization
;
neuromuscular transmission
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Experiments on isolated frog neuromuscular junctions in voltage-clamped conditions demonstrated increases in the probability of spontaneous release of quanta of mediator, resulting in increases in the K+ ion concentration in the perfusion solution, and changes in the endplate miniature current amplitude induced by increased quantum generation were studied. Factors promoting the desensitization of the post-synaptic cholinergic membrane (inhibition of acetylcholinesterase and addition of proadifen) to levels greater than a certain (critical) frequency of endplate miniature current of the order of 50 spikes/sec were found to result in accumulation of activity and progressive reductions in the sensitivity of the post-synaptic membrane to the mediator acetylcholine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02464803
