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5-Benzyluracil and its derivatives (1974)

German, L. S. ; Polishchuk, V. R. ; Bekker, G. Ya.

Springer

Chemistry of heterocyclic compounds 10 (1974), S. 1262-1262

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ISSN: 1573-8353

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract 5-(Hydroxybenzyl)uracils are obtained by condensation of 5-hydroxymethyluracil (I) with phenols in the presence of CF3COOH [1]. However, the activity of CF3COOH is insufficient for aromatic compounds that do not contain electron-donor substituents. Thus, according to PMR data, the reaction between equivalent amounts of I and C6H6 in CF3COOH is complete only after 3 days. However, benzene derivatives containing electron-acceptor substituents are practically unreactive. Anhydrous HP, in which even benzotrifluoride reacts, is a considerably more efficient agent.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00470180

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