ISSN:
1573-4838
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Technology
Notes:
The plasma protein binding properties of four medical polyurethane materials were investigated. The polymers were Pellethane 2363-80AE, ethanol extracted Pellethane, a poly(ether urethaneurea) with a composition similar to Biomer and Containing an acrylic polymer additive, and the same polymer without the additive. The polymers were cast onto silicon wafers and then immersed in human plasma from solution followed by antisera. The deposition of organic material was measured with ellipsometry. All tested polymers displayed low anti-high molecular weight kininogen (α-HMWK), anti-Factor XII (α-F XII), and anti-fibronectin (α-FN) depositions. Polymers containing additives also showed significantly lowered binding of anti-fibrinogen (α-FG). The results show that protein binding to the tested polyurethane surfaces were largely modulated by surface active processing aids, and can be conveniently analysed using antisera techniques.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00122286
