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Combined preparative enzymatic synthesis of dTDP-6-deoxy-4-keto-D-glucose from dTDP and sucrose (1998)

Stein, Andreas ; Kula, Maria-Regina ; Elling, Lothar

Springer

Glycoconjugate journal 15 (1998), S. 139-145

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ISSN: 1573-4986

Keywords: activated deoxysugars ; preparative enzymatic synthesis ; sucrose synthase ; dehydratase

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract dTDP–6–deoxy–4–keto–D–glucose (1), the common intermediate in the biosyntheses of the mainfold deoxysugars, was synthesized on a gram–scale by the combination of sucrose synthase and dTDP–D–glucose 4,6–dehydratase in a fed batch, starting the reaction with dTDP. This process allowed a dTDP conversion with a 100% rate. An easy and efficient three–step purification with anion–exchange chromatography and gel filtration gave 1.1 g of 1 in an overall yield of 73%. This work realizes a first step for an economic access to activated deoxysugars.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1006912121278

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