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Flavonoids as inhibitors of rat liver cytosolic glutathione S-transferase (1991)

Merlos, M. ; Sanchez, R. M. ; Camarasa, J. ; [et al.]

Springer

Cellular and molecular life sciences 47 (1991), S. 616-619

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ISSN: 1420-9071

Keywords: Flavonoids ; glutathione S-transferase ; quercetin ; rat liver cytosol

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The inhibitory potencies of different flavonoids for rat liver cytosolic glutathione S-transferase activity varied over 30-fold, depending on the pattern of hydroxylation, the presence of a C-2, C-3 double bond and the substitution of a hydroxyl group with a sugar moiety. Kinetic inactivation studies of the enzyme with the inhibitor quercetin revealed a non-competitive profile versus both glutathione and 1-chloro-2,4-dinitrobenzene.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01949888

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