ISSN:
1420-9071
Keywords:
Hypertension
;
hypotension
;
vascular compensation
;
vascular decompensation
;
hemorrhage
;
shock
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The data suggest that rats genetically inbred to be hypertensive (SHR) are less able to compensate for hemorrhage and shock than their normotensive controls (WKY). Two reasons for this genetic dysfunction are: 1) SHRs seem to depend more on innervated alpha 1 than noninnervated alpha 2 adrenoreceptors for vasoconstriction; and 2) the vascular smooth muscle hypertrophy noted in SHRs may interfere with effective vasoconstriction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02007680